P-023 eNOS polymorphisms in relation to outcome in advanced HCC patients receiving sorafenib
نویسندگان
چکیده
منابع مشابه
eNOS polymorphisms and clinical outcome in advanced HCC patients receiving sorafenib: final results of the ePHAS study
Sorafenib may reduce endothelial nitric oxide synthase (eNOS) activity by inhibiting vascular endothelial growth factor receptors (VEGF-R), leading to a decrease in nitric oxide production. In the Italian multicenter ePHAS (eNOS polymorphisms in HCC and sorafenib) study, we analyzed the role of eNOS polymorphisms in relation to clinical outcome in patients with hepatocellular carcinoma (HCC) re...
متن کاملPredictive role of the neutrophil-to-lymphocyte ratio in patients with advanced hepatocellular carcinoma receiving sorafenib.
We read the recently published article entitled ‘The Blood Neutrophil-to-lymphocyte Ratio Predicts Survival in Patients with Advanced Hepatocellular Carcinoma Receiving Sorafenib’ by Zheng et al. (2013), with interest. In the mentioned article authors aimed to determine the prognostic significance of the blood neutrophil-to-lymphocyte ratio (NLR) in patients with advanced hepatocellular carcino...
متن کاملThe blood neutrophil-to-lymphocyte ratio predicts survival in patients with advanced hepatocellular carcinoma receiving sorafenib.
BACKGROUND AND AIM Increasing evidence correlates the presence of systemic inflammation with poor survival in patients with hepatocellular carcinoma (HCC). The aim of this study was to investigate the prognostic significance of the blood neutrophil-to-lymphocyte ratio (NLR) in patients with advanced HCC who received sorafenib monotherapy. METHODS A total of sixty-five patients with advanced H...
متن کاملP 023
Ageing is associated with a shift in normal patterns of DNA methyla-tion, including increased methylation of CpG islands. This may have significant effects on gene expression and could, in part, underlie the strong association between ageing and human disease. To study the extent and variability of age-associated methylation, we have studied peripheral blood leukocyte (PBL) DNA samples from 490...
متن کاملefl teachers job satisfaction and social capital in relation to students’ motivation
abstract this mixed method study examines whether there is any relationship among the variables of the study (job satisfaction, social capital and motivation). the researcher considered job satisfaction and social capital as independent variables; motivation is the dependent variable of the study. the researcher applied a questionnaire to assess each variable. to measure efl teachers’ job sati...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2015
ISSN: 0923-7534
DOI: 10.1093/annonc/mdv233.23